منابع مشابه
A License to Kill
Much of our knowledge of the basal mechanism underly-44 Lincoln's Inn Fields ing programmed cell death derives from the elegant London WC2A 3PX studies of Horvitz and colleagues on developmental cell United Kingdom death in the developmentally deterministic nematode worm Caenorhabditis elegans. During development of Apoptosis is the descriptive name given to the process the hermaphrodite worm, ...
متن کاملIFNγ: Issuing macrophages a license to kill
T cells tell macrophages when to start making the toxic soup of lysosomal enzymes, reactive oxygen species, and nitric oxide that destroys intracellular pathogens. In 1983, Carl Nathan proved that this start signal comes in the form of the secreted cytokine IFNgamma.
متن کاملLicense to kill: IFN-λ regulates antifungal activity of neutrophils.
Interferon-λ mediates antifungal immunity by stimulating neutrophils to generate reactive oxygen species.
متن کاملNK cells kill mycobacteria directly by releasing perforin and granulysin.
Although the mechanisms underlying the cytotoxic effect of NK cells on tumor cells and intracellular bacteria have been studied extensively, it remains unclear how these cells kill extracellular bacterial pathogens. In this study, we examine how human NK cells kill Mycobacterium kansasii and M.tb. The underlying mechanism is contact dependent and requires two cytolytic proteins: perforin and gr...
متن کامل"License to kill" reflects joint action of CD4 and CD8 T cells.
The spontaneous T-cell responses to the KIF20A cancer-associated antigen found by Tomita and colleagues among peripheral blood mononuclear cells of patients with cancer, but not healthy people, involve both CD4 and CD8 T cells. Synthetic long peptides of KIF20A stimulate synergy between these two T-cell types to promote cancer cell killing.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Reviews Immunology
سال: 2005
ISSN: 1474-1733,1474-1741
DOI: 10.1038/nri1691